[Dual antiplatelet therapy in elderly patients with acute coronary syndrome: does age make the difference?]. in Giornale italiano di cardiologia (2006) / G Ital Cardiol (Rome). 2018 Jul-Aug;19(7):420-428. doi: 10.1714/2938.29538.
2018
AO Cuneo
Tipo pubblicazione
Journal Article
Autori/Collaboratori (12)Vedi tutti...
Marchionni N
Cattedra di Geriatria, Università degli Studi, e S.O.D. Cardiologia e Medicina Geriatrica, Azienda Ospedaliero-Universitaria Careggi, Firenze.
Cavallini C
Divisione di Cardiologia, Ospedale S. Maria della Misericordia, Perugia.
Musumeci G
U.S.C. Cardiologia, Ospedale Santa Croce e Carle, Cuneo.
et alii...
Abstract
The appropriate use of dual antiplatelet therapy (DAPT) in elderly patients with acute coronary syndrome (ACS) remains a highly debated subject. In fact, achieving the correct balance between the reduction of ischemic risk and the increase in hemorrhagic events is more difficult in this population than in younger subjects, especially in the case of very potent drug therapy. As a consequence of this, despite guideline recommendations, antiplatelet therapy is currently underutilized in elderly patients with ACS.In current clinical practice, the antiplatelet drugs that can be used in combination with aspirin are clopidogrel, prasugrel and ticagrelor. The efficacy of these molecules is supported by randomized clinical trials, which gave variable results in terms of the extent of reduction in ischemic events and increase in hemorrhagic complications. The purpose of this article is to identify, based on the results of a consensus meeting, common elements in the use of DAPT in the elderly and to identify areas where further scientific evidence is required to better define the role of the individual antiplatelet agents.
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PMID : 29989599
DOI : 10.1714/2938.29538
Keywords
Randomized Controlled Trials as Topic; Practice Guidelines as Topic; Humans; Platelet Aggregation Inhibitors/administration & dosage/adverse effects; Drug Therapy, Combination; Aspirin/administration & dosage/adverse effects; Aged; Age Factors; Acute Coronary Syndrome/drug therapy;